The terminal Pleistocene witnessed significant paleoclimatic changes that influenced the adaptive behavior of human populations. Situated in the tropical-subtropical zone of Southwest China, a newly excavated cave site, Fodongdi, revealed evidence for substantive changes in technology between 18.37 to 13.85 cal ka BP. Here, we present the results of a technological analysis on lithic assemblage formation across three main sequential phases at Fodongdi Cave. Diachronic changes in lithic technology document the co-existence of diverse reduction techniques and toolkits, corresponding with climatic fluctuations over a five-thousand-year period.